"Does Mounjaro make you tired?" is a common question among people considering or already using this injectable weight loss treatment. Feeling more tired than usual can be concerning, especially if it affects work, exercise, or daily routines. Understanding whether tiredness is a recognised side effect, why it may happen, and how long it tends to last can help you feel more prepared and reassured during treatment.
At Manchester Weight Loss Clinic, we support patients with clear, practical guidance on what to expect when starting Mounjaro. Side effects can vary between individuals, and knowing what is considered normal versus when to seek advice plays an important role in using the medication safely and confidently.
Can Mounjaro Cause Tiredness?
Tiredness or fatigue has been reported by some people using Mounjaro, particularly during the early stages of treatment or following a dose increase. While it is not experienced by everyone, it is recognised as a possible side effect. This tiredness is usually described as mild to moderate and often improves as the body adjusts to the medication.
Mounjaro works by influencing hormones involved in appetite regulation and blood sugar control. These changes can temporarily affect energy levels, especially while your body adapts to eating smaller portions or consuming fewer calories. Call us if you are unsure whether the tiredness you are experiencing is related to Mounjaro or something else.
Why You Might Feel More Tired on Mounjaro
There are several reasons why tiredness may occur during Mounjaro treatment. In many cases, it is linked to changes in eating habits rather than the medication itself. Reduced appetite can lead to a lower calorie intake, which may temporarily affect energy levels until your body adjusts.
Other contributing factors can include mild dehydration, changes in blood sugar levels, or gastrointestinal side effects such as nausea, which may reduce overall food intake. For some people, the effort of adapting to new routines and dietary patterns can also contribute to feeling more fatigued in the short term.
- Reduced calorie intake due to lower appetite
- Temporary changes in blood sugar levels
- Mild dehydration if fluid intake is reduced
- Adjusting to new eating patterns
Is Tiredness More Common at the Start?
Many patients report that tiredness is more noticeable during the first few weeks of treatment or after increasing their dose. This is often when appetite suppression is strongest and dietary changes are most significant. As your body becomes accustomed to Mounjaro, energy levels usually stabilise.
If tiredness persists beyond the initial adjustment period or begins to worsen, it is important to seek professional advice to rule out other causes.
How to Manage Tiredness While Using Mounjaro
Managing tiredness during Mounjaro treatment often involves making small but effective adjustments. Ensuring you are eating balanced meals with enough protein, staying well hydrated, and maintaining regular sleep patterns can all help support energy levels.
Gentle physical activity, such as walking, can also improve circulation and reduce fatigue, even if motivation feels low initially. Contact us if you would like personalised advice on managing side effects while continuing treatment safely.
When Tiredness on Mounjaro May Need Further Review
While mild tiredness can be a normal part of adjusting to Mounjaro, certain symptoms should not be ignored. Persistent fatigue that interferes with daily life, dizziness, weakness, or symptoms that do not improve over time may indicate the need for review.
Other factors such as vitamin deficiencies, poor sleep, stress, or unrelated medical conditions can also cause tiredness. A professional assessment helps ensure the cause is identified and managed appropriately.
Balancing Expectations With Mounjaro Treatment
An awareness of the early side effects helps reduce anxiety and encourages realistic expectations. Many people find that the benefits of treatment, such as appetite control and gradual weight loss, outweigh short-term side effects such as tiredness.
Ongoing monitoring and regular check ins allow treatment to be adjusted if needed, ensuring it remains safe and effective. At Manchester Weight Loss Clinic, we offer personalised support every step of the way during your weight loss journey. If one of your new year resolutions is to achieve your weight loss goals, take a look at our recent TikTok to find out how we can support you:
@heald.green.pharm Weight-loss goals for 2026? ✨ Weightloss Manchester in Heald Green Pharmacy have the solution for you with real results and professional support every step of the way. #2026 #weightgoals #health #support #pharmacy ♬ original sound - Heald Green Pharmacy
Weight Loss Support at Manchester Weight Loss Clinic
"Does Mounjaro make you tired?" is an important question, and the answer can vary from person to person. Knowing what is typical, how to manage symptoms, and when to seek advice helps you stay confident and supported throughout your weight loss journey.
Book now to arrange a consultation at Manchester Weight Loss Clinic and discuss Mounjaro side effects, suitability, and personalised weight management support with our experienced team.
This blog was written on behalf of Manchester Weight Loss Clinic by Pharmacy Mentor.